Translational Readiness Tiers
Each exerkine is assigned a tier reflecting its stage along the bench-to-bedside pipeline:
1 Clinically Validated — Approved therapeutics or advanced clinical trials with regulatory milestones
2 Clinical Trials — Active or completed human trials; strong mechanistic and preclinical evidence
3 Preclinical Promise — Robust in vivo data in animal models; clinical translation not yet initiated
4 Emerging Targets — Early-stage research with suggestive but limited evidence; further validation required
Therapeutic Domains & Evidence Symbols
The table scores each exerkine across six therapeutic domains based on the strength and breadth of published evidence:
Evidence symbols
●● Primary domain (strongest evidence)
● Established evidence
○ Preliminary evidence
○* Dual / complex role
●(t) Target for inhibition
— Not reported
| Exerkine | Tier | Source Tissue | CV | Met | Neuro | MSK | Inflam | Onco |
|---|